Meta-analyses by Van Howe and Bosch et all of observational studies reached differing conclusions as to whether circumcision reduces infection with human papillomavirus (HPV).
A recent prospective trial in Uganda randomized 3393 subjects to circumcision or a control group and found a significant reduction of HPV infection in the circumcision group. At 24 month follow-up, there was a 27.9% prevalence of high-risk HPV genotypes in the control group and only a 18.0% prevalence in the circumcision group (adjusted risk ratio, 0.65; 95% CI, 0.46 to 0.90; P=0.009). Another recent trial by Auvert et al. in Orange Farm, South Africa, randomized men to either a circumcision or control group. At the 21 month visit, the prevalence of high-risk HPV infection was lower in the circumcised men than the uncircumcised participants (14.8% and 22.3% respectively, a prevalence rate ratio of 0.66) in the absence of any difference in reported sexual behaviour or gonorrhea prevalence
Two studies have shown that circumcised men report, or were found to have, a higher prevalence of genital warts than uncircumcised men; however, a 2009 meta-analysis of multiple studies found a non-significant association between genital warts and the presence of a foreskin.
http://en.wikipedia.org/wiki/Circumcision#Medical_aspects
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